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Begin by limiting use to twice a week, then gradually increase frequency to every other night, and finally once an evening as tolerated. Apply a pea-sized amount of Retinol .5 to thoroughly cleansed skin in the evening. Carefully avoid the eyes and the corner of the eyes. To ensure optimal results, wait at least 30 minutes before applying any corrective or moisturizing products the same evening as applying Skinceuticals retinol.